Education:

Doctor of Medicine State University of New York Health Sciences Center	May 1989 Stony Brook
Bachelor of Arts in Biology The Johns Hopkins University	May 1985 Baltimore, Maryland

Postgraduate Training / Experience

July 1997 - Present:
Director of Urologic Oncology, Department of Surgery, at Staten Island University Hospital.

July 1996 - June 1997:
Clinical fellow in Urologic Oncology, Memorial Sloan-Kettering Cancer Center New York, N.Y.

July 1992 - June 1996:
Resident and Chief Resident in Urology, Maimonides Medical Center Brooklyn, New York. Chairman: Dr. Gilbert J. Wise.

July 1991 - June 1993:
National Cancer Institute fellow in prostate cancer research at Memorial Sloan-Kettering Cancer Center. Laboratory of Dr. William R. Fair and Warren Heston.

July 1991 - June 1992:
Assistant attending in emergency medicine in the Department of Adult Emergency Services at the Kings County Hospital Center Brooklyn, N.Y.

July 1989 - June 1991:
Internship and residency training in General Surgery at the State University of New York Health Sciences Center at Brooklyn/Kings County Hospital Center.

Licensure:

Passed Urology Board Qualifying Examination June 1996

Professional Society Memberships:

American Medical Association Medical Society of the State of New York American Association for Cancer Research Johns Hopkins Alumni Association American Urological Association New York Section - AUA Richmond County Medical Society

1985 - Present 1991 - Present 1985 - Present 1992 - Present 1985 - Present 1992 - Present 1997 - Present

Honors and Awards:

1996: Winner of First Annual Pfizer Urology award for overall excellence in both urologic research and clinical urology.

1995: "Outstanding poster" award at the 86th Annual Meeting of the American Association for Cancer Research in Translational Aspects of Prostatic Cancer session, Toronto, Canada. Presentation: "Neoadjuvant androgen-deprivation therapy (ADT) prior to radical prostatectomy results in a significant decrease in residual micrometastases as detected by nested RT-PCR with PSM primers".

1994: First prize award for clinical research in the Circon/ACMI AUA Essay Contest. Title: "Sensitive detection of prostatic hematogenous micrometastases using PSA and PSM-derived primers in the polymerase chain reaction".

1994: "Best poster" award at the 89th Annual Meeting of the AUA in Prostate Cancer - Basic session, San Francisco, CA. Presentation: "Localization of the Prostate-specific Membrane Antigen to the putative metastasis-suppressor region on human chromosome 11".

1994:Honorable mention for laboratory research in the AUA-New York section F.C. Valentine resident essay contest. Title of paper: "Sensitive detection of occult prostatic hematogenous micrometastases".

1993: First prize for laboratory research in the AUA-New York section F.C. Valentine resident essay contest. Title of paper: "Molecular characterization of the Prostate-specific Membrane Antigen".

1991-93 National Cancer Institute research fellowship award.

1989: Diplomate of the National Board of Medical Examiners.

1985-88: Honors in coursework at SUNY - Stony Brook School of Medicine.

1985-87: Research scholarship at SUNY - Stony Brook School of Medicine.

1984-85: Biology research award - Johns Hopkins University.

1982-85: Dean's List at the Johns Hopkins University.

Grants:

1993-97: Investigator. NIH DK47650. George M. O'Brien Urology Research Center. Urologic Oncology Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York.

1993-94: Maimonides Research and Development Foundation Grant - "Sensitive detection of occult prostatic hematogenous micrometastases".

1992-93: Maimonides Research and Development Foundation Grant - "Molecular Characterization of the Prostate-Specific Membrane Antigen". Award:

1991 - 1993: NCI research fellow award. NIH grant CA-09501-07.

Patents:

The Prostate-Specific Membrane Antigen.
U.S. Serial No. 5538866
Filed November 5, 1992.
International patent application filed November 1993.
Patents granted July 23, 1996.
Licensed in part to Cytogen Corporation, Princeton, N.J.

Research Experience:

1991 - 1993:
Urology research fellow in the Urologic Oncology Research Laboratory at Memorial Sloan-Kettering Cancer Center headed by Drs. William R. Fair and Warren D.W. Heston. I purified PSM, the prostate specific membrane antigen, cloned the cDNA encoding it, and have localized the PSM gene to human chromosome 11. Subsequent work has involved the characterization of this new Research Experience antigen, development of anti-PSM antibodies, and the design of a PCR-based test to detect occult prostatic hematogenous micrometastases using PSM primers.

1986 - 1987:
Medical student in the laboratory of Dr. Michael Viola of the Division of Medical Oncology at SUNY-Stony Brook School of Medicine. Projects involved the construction of genomic DNA libraries from human melanoma tumors and cell lines in order to isolate the tyrosinase gene.

1984 - 1985:
Oncology research in the laboratory of Dr. Paula Pitha-Rowe of the Johns Hopkins Oncology Center. I studied the anti-viral and anti-tumor activities of the human and murine * and * interferons and examined mechanisms of interferon gene inducibility, transcriptional control, and regulation of expression.

1982 - 1984:
Molecular biology research in the laboratory of Dr. Victor Corces of the Johns Hopkins University Department of Biology. I studied the regulation and expression of the hsp70 heat shock gene in Drosophila melanogaster.

Publications:

1. N.B.K. Raj, R. Israeli, K.A. Kelley, S.J. Leach, E. Minasian, K. Sikaris, D.A.D. Parry, and Pitha, P.M.. Synthesis, antiviral activity, and conformational characterization of mouse-human *-interferon hybrids. J. Biol. Chem., 263: 8943, 1988.

2. N.B.K. Raj, R.S. Israeli, M. Kellum, and Pitha, P.M.. Upstream regulatory elements of murine *-4-interferon gene confer inducibility and cell type-restricted expression. J. Biol. Chem., 264: 11149, 1989.

3. Israeli, R.S., Powell, C.T., Fair, W.R., and Heston, W.D.W. Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. Cancer Res., 53: 227, 1993.

4. Israeli, R.S., Powell, C.T., Corr, J.G., Fair, W.R., and Heston, W.D.W. Expression of the Prostate-Specific Membrane Antigen (PSM). Cancer Res., 54: 1807, 1994.

5. Israeli, R.S., Miller, W.H., Jr., Su, S.L., Powell, C.T., Fair, W.R., Samadi, D.S., Huryk, R.F., DeBlasio, A., Edwards, E.T., and Heston, W.D.W. Sensitive nested RT-PCR detection of circulating prostatic tumor cells - comparison of PSM and PSA-based assays. Cancer Res., 54: 6306, 1994.

6. Donat, S. M., Powell, C.T., Israeli, R.S., Fair, W.R., and Heston, W.D.W. Transferrin reverses the cytostatic effect of suramin in human prostate cancer in-vitro: Potential clinical implications. J. Natl. Can. Inst., 87: 41, 1995.

7. Israeli, R.S., Miller, W.H., Su, S.L., Samadi, D.S., Powell, C.T., DeBlasio, A., Huryk, R., Fair, W.R., Wise, G.J., and Heston, W.D.W. Sensitive detection of prostatic hematogenous micrometastases using PSA and PSM-derived primers in the polymerase chain reaction. J. Urol., 153: 573, 1995.

8. Israeli, R.S., Wise, G.J., Bansal, S., Gerard, P.S., and A. Castella. Bilateral renal oncocytomatosis in a patient with renal failure.: A case report. Urology, 46: 873, 1995.

9. Rinker-Schaeffer, C.W.,Su, S.L., Israeli, R.S., Powell, C.T., Isaacs, J.T., and Heston, W.D.W. Localization of the Prostate-Specific Membrane Antigen (PSM) to the putative metastasis-suppressor region on human chromosome 11. Genomics, 30: 105, 1995.

10. Israeli, R.S., and Fair, W.R. The polymerase chain reaction: Applications in Urology. AUA Update Series Volume XVI, Lesson 4, 1997.

11. Fair, W.R., Israeli, R.S and Heston, W.D.W.. The Prostate Specific Membrane Antigen (PSM): Review Article. The Prostate, 32: 140, 1997.

12. Goldman, H.B., Israeli, R.S., Lerner, J.L., Steiner, M.S. Can PSA RT-PCR be used as a prospective test to diagnose prostate cancer? World Journal of Urology, 15(4): 257, 1997.

13. Israeli, R.S. and Fair, W.R. Prostate-specific membrane antigen (PSM) and other prostatic tumor markers on the horizon. Urologic Clinics of North America, 1997.

14. Goldman, H.B., Israeli, R.S., Lerner, J.L., Steiner, M.S. Effect of prostate needle biopsy on results of the PSA RT-PCR assay. Manuscript in press - Urology, 1998.

15. Israeli, R.S. and Fair, W.R. Urologic applications of the polymerase chain reaction. Manuscript submitted - World Journal of Urology 1998.

16. Israeli, R.S. and Fair, W.R. The prostate-specific membrane antigen (PSM): Basic science and clinical applications. Manuscript submitted - World Journal of Urology 1998.

17. Israeli, R.S., Green, I., Reuter, V., and Russo, P. Renal cell carcinoma metastasizing to the ureteral stump: A case report and review of the literature. Manuscript submitted - Urology.

18. Israeli, R.S., Heston, W.D.W., and Fair, W.R. Neoadjuvant androgen-deprivation therapy preceding radical prostatectomy results in a significantly decreased incidence of residual micrometastatic disease as detected by nested RT-PCR with PSM-derived primers. Manuscript submitted - Urologic Oncology.

Abstracts and Presentations:

1. Raj, N.B.K., Israeli, R.S., Kelley, K.A., Kellum, M., and Pitha, P.M. Amino acid sequences involved in the antiviral species specificity of human and murine *- interferons. 1985 TNO/ISIR Meeting on the Interferon System, Clearwater Beach, Florida, 1985.

2. Pitha, P.M., Mosca, J., Israeli, R.S., Biegel, D., and Raj, N.B.K. Multiple steps regulating the expression of interferon genes. 1985 TNO/ISIR Meeting on the Interferon System, Clearwater Beach, Florida, 1985.

3. Israeli, R.S., Kelley, K.A., Kellum, M., Pitha, P.M., and Raj, N.B.K. Amino acid sequences involved in the antiviral species specificity of human and murine *- interferons. Molecular Biology Summer Symposium at Pennsylvania State University, 1985.

4. Raj, N.B.K., Israeli, R.S., Kelley, K.A., Kellum, M., and Pitha, P.M. Species specificity of the human and murine *- interferons is determined by the amino acid sequences. UCLA Symposium on Interferons as Cell Growth Inhibitors and Anti-Tumor Factors, Steamboat Springs, Colorado, 1986.

5. Raj, N.B.K., Israeli, R.S., Kellum, M., Gwynn, D., and Pitha, P.M. A 36 nucleotide fragment from the promoter region of *- interferon is sufficient for inducible expression of murine *- interferon genes. 6th Annual Stony Brook Symposium on New Insights into the Regulation of Transcription, Stony Brook, New York, 1987.

6. Pitha, P.M., Israeli, R.S., Kelley, K.A., Leach, S.J., Minasian, E., Sikaris, K., Parry, D., and Raj, N.B.K. Structure-activity relationships among the *- interferons. ISIR/ASM Meeting on the Interferon System, Wash., D.C., 1987.

7. Raj, N.B.K., Israeli, R.S., Kellum, M., Gwynn, D., and Pitha, P.M. A 36 nucleotide fragement from the promoter region of *- interferon is sufficient for the inducible expression of murine *- interferon genes. ISIR/ASM Meeting on the Interferon System, Wash., D.C., 1987.

8. Israeli, R.S. Invited Speaker - Memorial Sloan-Kettering Cancer Center Surgical Research Conference, January 20, 1992. Talk: Gene therapy using genetically engineered myoblasts.

9. Israeli, R.S., Powell, C.T., Fair, W.R., and Heston, W.D.W. Purification and molecular cloning of a new prostate-specific antigen. 83rd Annual Meeting of the A.A.C.R., San Diego, CA., 1992.

10. Israeli, R.S. Invited Speaker - Memorial Sloan-Kettering Cancer Center Surgical Research Conference, June 8, 1992. Talk: Molecular cloning of the prostate-specific membrane antigen - PSM".

11. Israeli, R.S. Invited Speaker - Memorial Sloan-Kettering Cancer Center Surgical Research Conference, November 12, 1992. Talk: Expression and further characterization of the prostate-specific membrane antigen - PSM.

12. Israeli, R.S. Invited Speaker - The Johns Hopkins University Oncology Center Multidisciplinary Research Conference, November 30, 1992. Talk: Characterization of a new prostate-specific antigen - PSM".

13. Israeli, R.S. Essay finalist, F.C. Valentine Urology Essay Contest, New York Section - AUA. Title: Molecular characterization of the prostate-specific membrane antigen, March 31, 1993.

14. Fair, W.R., Israeli, R.S., Powell, C.T., and Heston, W.D.W. Expression of Prostate Specific Membrane Antigen (PSM) in human cell lines and tissues. 107th Meeting of the American Association of Genitourinary Surgeons. Phoenix, AZ., 1993.

15. Israeli, R.S., Powell, C.T., Fair, W.R., and Heston, W.D.W. Molecular cloning and characterization of a prostate-specific membrane antigen. 88th Annual Meeting of the A.U.A., San Antonio, TX., 1993.

16. Israeli, R.S., Powell, C.T., Fair, W.R., and Heston, W.D.W. Charac-terization of the Prostate-Specific Membrane Antigen (PSM). 84th Annual Meeting of the A.A.C.R., Orlando, FL., 1993.

17. Israeli, R.S. Guest speaker, Prostate Cryosurgery Conference, Dept. of Urology, SUNY at Stony Brook, N.Y. Title: Identification of a new prostate-specific antigen, January 14, 1994.

18. Israeli, R.S. Guest Speaker, Urology Distinguished Visiting Professor Lecture Series, Dept. of Urology, SUNY at Stony Brook, N.Y. Title: The Prostate Specific Membrane Antigen (PSM), March 18, 1994.

19. Israeli, R.S. Essay finalist, F.C. Valentine Urology Essay Contest, New York Section - AUA. Title: Sensitive detection of occult prostatic hematogenous micrometastases, April 13, 1994.

20. Su, S.L., Israeli, R.S., Miller, W.H., Samadi, D.S., Powell, C.T., Fair, W.R., and Heston, W.D.W. Sensitive detection of prostatic hematogenous micrometas- tases using Prostate-specific antigen (PSA) and Prostate-specific membrane antigen (PSM) derived primers in the polymerase chain reaction. 85th Annual Meeting of the A.A.C.R. San Francisco, CA., April 1994.

21. Israeli, R.S., Rinker-Schaeffer, C.W., Powell, C.T., Isaacs, J.T., Fair, W.R., and Heston, W.D.W. Localization of the Prostate-specific Membrane Antigen (PSM) to the putative metastasis-suppressor region on human chromosome 11. 85th Annual Meeting of the A.A.C.R., San Francisco, CA., 1994.

22. Israeli, R.S., Miller, W.H., Su, S.L., Samadi, D.S., Powell, C.T., DeBlasio, A., Huryk, R., Fair, W.R., Wise, G.J., and Heston, W.D.W. Sensitive detection of prostatic hematogenous micrometastases using PSA and PSM-derived primers in the polymerase chain reaction. 89th Annual Meeting of the A.U.A., San Francisco, CA., 1994.

23. Israeli, R.S., Rinker-Schaeffer, C.W., Powell, C.T., Isaacs, J.T., Fair, W.R., and Heston, W.D.W. Localization of the prostate-specific membrane antigen to the putative metastasis-suppressor region on human chromosome 11. 89th Annual Meeting of the A.U.A., San Francisco, CA., 1994.

24. Corr, J.G., Israeli, R.S., Huryk, R., Fair, W.R., and Heston, W.D.W. Prostate-specific membrane antigen expression in orthotopically implanted human prostate cancer cells in nude mice slows tumor growth and metastatic potential. 89th Annual Meeting of the A.U.A., San Francisco, CA., 1994.

25. Israeli, R.S. Ureteral metastasis from renal cell carcinoma. Guest speaker at the weekly Urology Service Conference, Memorial Sloan-Kettering Cancer Center, July 25, 1995.

26. Israeli, R.S., Wang, Y., Fair, W.R., Nawabi, M.D., Edwards, E.T., and Heston, W.D.W. Neoadjuvant androgen-deprivation therapy prior to radical pros- tatectomy results in a significant decrease in residual micrometastases as detected by nested RT-PCR with PSM primers. 86th Annual Meeting of the A.A.C.R., Toronto, Canada, 1995.

27. Israeli, R.S., Su, S.L., Fair, W.R., Nawabi, M.D., Huryk, R.F., Edwards, E.T., and Heston, W.D.W. PCR-based detection of occult circulating prostatic tumor cells - an analysis of 170 patient samples. 90th Annual Meeting of the A.U.A., Las Vegas, NV, 1995.

28. Fair, W.R., Israeli, R.S., Wang, Y., Nawabi, M.D., Edwards, E.T., and Heston, W.D.W. Neoadjuvant androgen-deprivation therapy prior to radical prostatectomy results in a significantly decreased incidence of residual micro- metastatic disease as detected by nested RT-PCR with PSM primers. 90th Annual Meeting of the A.U.A., Las Vegas, NV, 1995.

29. Israeli, R.S., Su, S.L., Fair, W.R., Miller, W.H., Jr., Powell, C.T., Huryk, R.F., Edwards, E.T., and Heston, W.D.W. Enhanced detection of prostatic hema-togenous micrometastases with PSM primers as compared to prostate specific antigen primers using a sensitive nested reverse transcriptase-PCR assay. 90th Annual Meeting of the A.U.A., Las Vegas, NV, 1995.

30. Israeli, R.S. The prostate-specific membrane antigen (PSM): Charac-terization and molecular staging applications using RT-PCR. Guest speaker at Cambridge Healthtech Institute "Prognostic Factors in Cancer" meeting June 7-8, 1995, Arlington, Virginia.

31. Israeli, R.S. Prostate Cancer: 1996. Keynote speaker at the Brooklyn Cancer Institute Prostate Cancer program held February 25, 1996, Brooklyn, N.Y.

32. Israeli, R.S., Winter, L., and Fair, W.R. The life and accomplishments of Dr. Willet F. Whitmore - Trailblazer in the field of Urologic Oncology. 91st Annual Meeting of the A.U.A., Orlando, FL, 1996.

33. Israeli, R.S. Polymerase chain reaction - Urologic applications. Guest speaker at Urology grand rounds at the SUNY at Stony Brook School of Medicine, May 8, 1996. Abstracts and Presentations (cont.):

34. Israeli, R.S. The polymerase chain reaction (PCR) and its applications in Urology. Visiting Professor at the University of Tennessee School of Medicine, Memphis, TN., May 22, 1996.

35. Israeli, R.S. Management of elevated PSA following definitive treatment. Guest speaker at US TOO prostate cancer support group meeting at Memorial Sloan-Kettering Cancer Center, January 18, 1997.

36. Israeli, R.S. New research developments in prostate cancer, at the Ameri-can Cancer Society Forum on Prostate Cancer, New York City, June 26, 1997.

37. Israeli, R.S. New developments in the management of prostate cancer, at the Staten Island Kiwanis Club, Staten Island, N.Y., August 14, 1997.

38. Israeli, R.S. Management of clinically localized prostate cancer-a surgeon's perspective, at the American Cancer Society Forum on Prostate Cancer, New York City, September 25, 1997.

39. Israeli, R.S. Surgical management of localized prostate cancer, at the Staten Island University Hospital Multidisciplinary Conference on Prostate Cancer, Staten Island, N.Y., September 30, 1997.

40. Israeli, R.S. Diagnosis and treatment of prostate cancer, for the Staten Island Civic Association, Staten Island, N.Y., October 13, 1997.

41. Israeli, R.S. Prostate cancer 1997 - diagnosis and treatment options, for the Staten Island American Legion, Staten Island, N.Y., October 15, 1997.